dna damage response pathway

X dna damage induced by ros is considered one of the main causes of nucleus pulposus np cells degeneration during the progression of intervertebral disc degeneration ivdd. The dna damage theory of aging proposes that aging is a consequence of unrepaired accumulation of naturally occurring dna damages damage in this context is a dna alteration that has an abnormal structure. Recent studies have proved that cgas sting contributes to the development of various diseases.
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Nuclear dna damage can contribute to aging either indirectly by. Cgas sting pathway acts as dna sensing mechanism for monitoring dna damage. Chromatin remodeling is the dynamic modification of chromatin architecture to allow access of condensed genomic dna to the regulatory transcription machinery proteins and thereby control gene expression such remodeling is principally carried out by 1 covalent histone modifications by specific enzymes e g histone acetyltransferases hats deacetylases methyltransferases and kinases and.

Here we review the molecular mechanisms and cellular functions underlying cgas sting activation and signalling particularly highlighting the newly emerging diversity of this signalling pathway and discussing how the specificity towards normal damage induced and infection associated dna could be achieved.

Dna damage response pathway. Although both mitochondrial and nuclear dna damage can contribute to aging nuclear dna is the main subject of this analysis.