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https www alamy com i motif dna structure left computer illustration the intercalated motif i motif structure is a four stranded knot of dna deoxyribonucleic acid that forms in cytosine rich regions of a dna molecule cytosine is one of the four nucleotide bases of dna when forming a double helix cytosine bonds only with guanine however in i motif structures two cytosine bases bond to each other these structures were first seen in human cells in 2018 when an antibody y shaped molecule was found that recognises them i motif structures are thought to have a regulatory role in the genome image208255614 html