dna topoisomerase
Dna gyrase relaxes supercoiled dna molecules and initiates transient breakages and rejoins phosphodiester bonds in superhelical turns of closed circular dna. Unwinds the double helix at the replication fork. Topoisomerase ii is an enzyme that creates temporary double stranded dna dsdna breaks and reseals them after managing torsion of dna supercoils.
Relaxes the super coiled dna.

Dna topoisomerase. Also proofreads and corrects some errors. Provides the starting point for dna polymerase to begin synthesis of the new strand. Anthracyclines intercalated into dna form a stable anthracycline dna topoisomerase ii ternary complex thus poisoning the enzyme and impeding the religation of double stranded dna breaks. A dna polymerase is a member of a family of enzymes that catalyze the synthesis of dna molecules from nucleoside triphosphates the molecular precursors of dna these enzymes are essential for dna replication and usually work in groups to create two identical dna duplexes from a single original dna duplex.
The enzyme dna primase combines a short fragment of rna primer with the complementary constituents of the parent dna. During this process dna polymerase reads the existing dna strands to create two new. This process makes the two complementary parts of the double helix accessible to the replication enzymes.
role of nucleotide excision repair proteins in response to dna damage induced by topoisomerase ii inhibitors sciencedirect

























































































