dna damage foci hr nhej ssa
Leads to colocalization of fancd2 fanci with hr proteins in dna damage induced foci together with. This gene encodes a 190 kd nuclear phosphoprotein that plays a role in maintaining genomic stability and it also acts as a tumor suppressor. Removal of dna pk favors mmej ssa and hr 9 122.
Dna pk can be removed by phosphorylation of ku70 to reduce its dna binding affinity degradation of ku through ubiquitination or mrn mediated dna cleavage.
Dna damage foci hr nhej ssa. The major pathways of dna double strand break dsb repair are crucial for maintaining genomic stability. The encoded protein combines with other tumor suppressors dna damage sensors and signal transducers to form a large multi subunit protein complex known as the brca1 associated genome. Dna pk also binds dna ends and may commit cells to cnhej 10 109. However if deployed in an inappropriate cellular context these same repair functions can.
Reactome dna damage bypass reactome dna damage recognition in gg ner reactome dna damage reversal reactome dna damage telomere stress induced senescence reactome dna double strand break re pair reactome dna double strand break re sponse reactome dna methylation reactome dna repair reactome dna replication reactome dna replication initiation.
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